Zolpidem is a non-benzodiazepine hypnotic used for short-term insomnia.
Also known as: zolpidem, stilnox, ambien
Hypnotic + CYP3A4 inhibitor: ritonavir increases zolpidem levels 2-3-fold.
Zolpidem is metabolised by CYP3A4. Ritonavir inhibits CYP3A4, increasing levels.
Sedation, respiratory rate.
Excessive sedation.
Reduce zolpidem dose by 50%. Avoid driving.
DailyMed/FDA; EMC-EMC PT
No documented food or drink interactions.
No documented disease interactions.
CONTRAINDICATED in pregnancy.
CONTRAINDICATED.
Excreted in breast milk. Avoid.
Reliable contraception.
DailyMed/FDA; EMC-EMC PT
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
Selective GABA-Aω1 receptor agonist (hypnotic).
Selective binding to the α1 subunit of GABA-A. Sedation without significant anxiolytic, anticonvulsant or muscle relaxant effect.
Rapid oral absorption. Bioavailability: 70%. Peak: 0.5-3 h.
Metabolised by CYP3A4. Inactive metabolites.
2-5 h.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
