Lorazepam is a benzodiazepine used for anxiety, insomnia, epileptic seizures, and nausea/vomiting.
Also known as: lorazepam, ativan
Short half-life benzodiazepine. GABA-A agonist. No active metabolites.
Binding to the benzodiazepine site of the GABA-A receptor. Glucuronidation pathway (UGT2B7) — no active metabolites.
Complete oral absorption. Bioavailability: 80-90%.
Metabolised by glucuronidation (UGT2B7). No active metabolites — preferred in hepatic impairment.
10-20 h.
No documented drug–drug interactions for this medicine.
No documented food or drink interactions.
No documented disease interactions.
CONTRAINDICATED in 3rd trimester. Neonatal withdrawal syndrome.
CONTRAINDICATED in 3rd trimester.
Excreted in breast milk. Avoid.
Reliable contraception.
DailyMed/FDA; EMC-EMC PT
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
