Lorazepam is a benzodiazepine used for anxiety, insomnia, epileptic seizures, and nausea/vomiting.
Also known as: lorazepam, ativan
No documented drug–drug interactions for this medicine.
Alcohol adds CNS depression to lorazepam — excessive sedation, respiratory depression and motor impairment; Prontuário 10.1 (l. 30138): hypnotics and anxiolytics potentiate sedative effects.
Avoid alcohol completely during treatment.
Prontuário Terapêutico INFARMED, 10.1 (l. 30138); EMC-UK lorazepam SmPC 4.5.
No documented disease interactions.
CONTRAINDICATED in 3rd trimester. Neonatal withdrawal syndrome.
CONTRAINDICATED in 3rd trimester.
Excreted in breast milk. Avoid.
Reliable contraception.
DailyMed/FDA; EMC-EMC PT
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
Short half-life benzodiazepine. GABA-A agonist. No active metabolites.
Binding to the benzodiazepine site of the GABA-A receptor. Glucuronidation pathway (UGT2B7) — no active metabolites.
Complete oral absorption. Bioavailability: 80-90%.
Metabolised by glucuronidation (UGT2B7). No active metabolites — preferred in hepatic impairment.
10-20 h.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
