Quetiapine

Quetiapine is an atypical antipsychotic used for schizophrenia, bipolar disorder, and as adjunct in major depression.

Also known as: quetiapine, seroquel

Schizophrenia, bipolar disorder (mania, bipolar depression), adjunctive therapy in major depression.

Somnolence (dose-dependent), dizziness, dry mouth, weight gain, orthostatic hypotension, constipation, transaminase elevation.

Avoid in QTc >500 ms. Monitor glucose in diabetics. Pronounced somnolence — avoid driving. Risk of cataracts with prolonged use.

Pharmacology

D2, 5-HT2A, H1 and α1 antagonist. Norquetiapine (metabolite) inhibits noradrenaline reuptake.

Region-dependent D2 antagonism. High H1 affinity (sedation) and α1 (orthostatic hypotension). Norquetiapine contributes to antidepressant effect.

Rapid oral absorption. Bioavailability: 100%. Food increases absorption.

Metabolised by CYP3A4. Norquetiapine (active metabolite).

6-7 h (quetiapine); 12 h (norquetiapine).

Source

DailyMed/FDA — approved Quetiapine label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b

Source

DailyMed/FDA

Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.

No documented drug–drug interactions for this medicine.

No documented food or drink interactions.

No documented disease interactions.

No documented pregnancy or breastfeeding information.

Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.