Paroxetine is an SSRI used for depression, social anxiety disorder, OCD, and panic disorder.
Also known as: paroxetine, paxil, seroxat
CYP2D6 inhibitor SSRI + anti-hormonal: paroxetine reduces tamoxifen activity 60-80%.
Tamoxifen is activated by CYP2D6 to endoxifen. Paroxetine inhibits CYP2D6, reducing endoxifen formation 60-80%.
Compromised anti-tumoral efficacy.
Tumour growth.
CONTRAINDICATED. Switch to citalopram or escitalopram.
DailyMed/FDA; EMC-EMC PT
No documented food or drink interactions.
No documented disease interactions.
No documented pregnancy or breastfeeding information.
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
SSRI with highest SERT affinity. More anticholinergic effect than other SSRIs.
Potent serotonin reuptake inhibition (SERT). Anticholinergic effect (dry mouth, urinary retention). Inhibits CYP2D6.
Oral absorption. Bioavailability: 50%. Peak: 5-8 h.
Metabolised by CYP2D6 (polymorphic). Extensive first-pass metabolism.
21 h.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
