Natural oral penicillin (penicillin V)
Oral penicillin indicated for mild to moderately severe infections due to susceptible organisms, including streptococcal pharyngitis, rheumatic fever prophylaxis and odontogenic infections.
Also known as: Penicilina V, Fenoximetilpenicilina
DailyMed approved label (Penicillin V Potassium Tablet; setID 64ac283c-fe6a-49f0-ae85-90ab98e38272).
DailyMed approved label (Penicillin V Potassium Tablet; setID 64ac283c-fe6a-49f0-ae85-90ab98e38272).
No documented drug–drug interactions for this medicine.
Phenoxymethylpenicillin absorption is reduced when taken with food; taking on an empty stomach is recommended.
Take 1 hour before or 2 hours after meals.
DailyMed/FDA (NIH/NLM) — approved Penicillin V Potassium label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64ac283c-fe6a-49f0-ae85-90ab98e38272
No relevant pharmacokinetic interaction; usual moderation during treatment.
Moderate alcohol intake.
DailyMed/FDA (NIH/NLM) — approved Penicillin V Potassium label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64ac283c-fe6a-49f0-ae85-90ab98e38272
Phenoxymethylpenicillin is contraindicated in patients with documented penicillin allergy (risk of anaphylaxis).
Confirm allergy history before prescribing.
DailyMed/FDA (NIH/NLM) — approved Penicillin V Potassium label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64ac283c-fe6a-49f0-ae85-90ab98e38272
Phenoxymethylpenicillin elimination is reduced in severe renal impairment, with a risk of accumulation.
Adjust the interval in severe renal impairment.
DailyMed/FDA (NIH/NLM) — approved Penicillin V Potassium label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64ac283c-fe6a-49f0-ae85-90ab98e38272
Penicillins are considered safe in pregnancy.
May be used in any trimester when indicated.
Present in breast milk in small amounts; compatible with breastfeeding.
No specific contraception required.
DailyMed/FDA (NIH/NLM) — approved Penicillin V Potassium label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64ac283c-fe6a-49f0-ae85-90ab98e38272
Clinical and educational support tool. The information does not replace a medical prescription or the opinion of a qualified healthcare professional.
Bactericidal antibiotic that acts against sensitive microorganisms during active multiplication by inhibiting biosynthesis of cell-wall mucopeptide.
Inhibition of bacterial cell-wall synthesis (PBP binding); inactive against penicillinase-producing bacteria (many staphylococcal strains).
Penicillin V potassium is more resistant to gastric-acid inactivation than penicillin G; it may be given with meals, though blood levels are slightly higher when fasting. Average levels 2–5x higher than oral penicillin G.
Rapid renal excretion; only ~25% of the oral dose is recovered in urine, reflecting partial absorption.
Short half-life (~30 min); requires repeated administration throughout the day to maintain effective levels.
Medicines from the same therapeutic group (ATC classification) or the same pharmacological class.
