Monoamine oxidase B
Also known as: MAO-B, MAOB
Mitochondrial enzyme that preferentially degrades dopamine. It is selectively inhibited by selegiline and rasagiline, used in Parkinson's disease.
Selective MAO-B inhibition at therapeutic doses has lower tyramine interaction risk, but combination with serotonergic drugs (SSRIs, pethidine) retains serotonin syndrome risk.
Avoid combining selegiline with pethidine (potentially fatal documented interaction) and with SSRIs.
