Transporters

DAT

Dopamine transporter (SLC6A3)

Also known as: DAT, SLC6A3, dopamine-transporter

What it is

Uptake transporter (SLC6A3) located on dopaminergic terminals, which recycles dopamine into the neurone. It is the therapeutic target of psychostimulants (methylphenidate) and cocaine.

Role in interactions

DAT inhibition raises synaptic dopamine; drugs that inhibit DAT (methylphenidate, bupropion) can interact with other dopaminergic agents.

Common substrates

Substrates: dopamine (endogenous neurotransmitter).

Inhibitors

Inhibitors: methylphenidate, bupropion, cocaine, mazindol.

Inducers

Inducers: there are no clinically relevant inducers.

Clinical notes

Important in ADHD and substance dependence: bupropion (weak DAT and NET inhibitor) may reduce efficacy of dopaminergic drugs and potentiate seizures at high doses.

Source

DailyMed/FDA (NIH/NLM) — approved Bupropion label; EMC-UK (MHRA) — SmPC